Protective effects of thiamine pyrophosphate and cinnamon against oxidative liver damage induced by an isoniazid and rifampicin combination in rats.
Efectos protectores del pirofosfato de tiamina y la canela contra el daño hepático oxidativo inducido por la combinación de isoniazida y rifampicina en ratas.
Palabras clave:
isoniazida, rifampicina, pirofosfato de tiamina, extracto de canela, estrés oxidativo, inflamación
Resumen
Se ha demostrado que la isoniazida y la rifampicina (IRC) causan hepatotoxicidad tanto en estudios clínicos como preclínicos. El estrés oxidativo y la inflamación se han considerado responsables de la patogénesis de la hepatotoxicidad inducida por IRC. En estudios anteriores se han demostrado los efectos antioxidantes y antiinflamatorios del pirofosfato de tiamina (TPP) y del extracto de canela (CE). Por lo tanto, en nuestro estudio se investigaron los efectos protectores del TPP y el CE sobre el posible daño hepático causado por el tratamiento con IRC en ratas. Se clasificaron 24 ratas Wistar albinas en cuatro grupos: un grupo sano (HG), un grupo IRC (IRG), un grupo TPP+IRC (TIRG) y un grupo CE+IRC (CIRG). El TPP (25 mg/kg) se administró por vía intraperitoneal al TIRG, mientras que el CE (100 mg/kg) se administró por vía oral al CIRG. En IRG, TIRG y CIRG, se administró isoniazida (50 mg/kg) y rifampicina (50 mg/kg) por vía oral una hora después de estos tratamientos. Durante siete días, este procedimiento se repitió una vez al día. Tras este periodo, se tomaron muestras de sangre de las venas de la cola y se sacrificaron las ratas. Los tejidos hepáticos extraídos se analizaron en busca de citocinas oxidantes, antioxidantes y proinflamatorias y se sometieron a una evaluación histopatológica. También se midieron las actividades séricas de la alanina aminotransferasa y la aspartato aminotransferasa. Con el tratamiento con IRC se observó un aumento de los niveles de malondialdehído, factor nuclear kappa B, factor de necrosis tumoral alfa, interleucina 1 beta e interleucina 6, una disminución de los niveles totales de glutatión y de las actividades de superóxido dismutasa y catalasa, y un aumento de las actividades de alanina aminotransferasa y aspartato aminotransferasa (p<0,001). El análisis histopatológico del IRG sugirió hepatotoxicidad (p<0,001). El TPP y el CE administrados con el IRC inhibieron los cambios bioquímicos (p<0,001). En el TIRG, esta inhibición fue mayor que en el CIRG (p<0,05). El daño histoló-gico fue inhibido por el TPP (p<0,001). El CE previno los cambios bioquímicos pero no los histológicos, excepto la infiltración de células inflamatorias. Por lo tanto, TPP puede ser una mejor opción que CE para la prevención de la hepatotoxicidad inducida por IRC.
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Combrink M, du Preez I. Metabolomics describes previously unknown toxicity mechanisms of isoniazid and rifampicin. Toxicol Lett 2020;322:104-110.
Suárez I, Fünger SM, Kröger S, Rademacher J, Fätkenheuer G, Rybniker J. The diagnosis and treatment of tuberculosis. Dtsch Arztebl Int 2019;116:729-735.
Forget EJ, Menzies D. Adverse reactions to first-line antituberculosis drugs. Expert Opin Drug Saf 2006;5:231-249.
Yew WW, Chang KC, Chan DP. Oxidative stress and first-line antituberculosis drug-induced hepatotoxicity. Antimicrob Agents Chemother 2018;62:e02637-17
Song L, Zhang ZR, Zhang JL, Zhu XB, He L, Shi Z, Gao L, Li Y, Hu B, Feng FM. MicroRNA-122 is involved in oxidative stress in isoniazid-induced liver injury in mice. Genet Mol Res 2015;14:13258-13265.
Ahadpour M, Eskandari MR, Mashayekhi V, Haj Mohammad Ebrahim Tehrani K, Jafarian I, Naserzadeh P, Hosseini MJ. Mitochondrial oxidative stress and dysfunction induced by isoniazid: study on isolated rat liver and brain mitochondria. Drug Chem Toxicol 2016;39:224-232.
Shuhendler AJ, Pu K, Cui L, Uetrecht JP, Rao J. Real-time imaging of oxidative and nitrosative stress in the liver of live animals for drug-toxicity testing. Nat Biotechnol 2014;32:373-380.
Askgaard DS, Wilcke T, Døssing M. He patotoxicity caused by the combined action of isoniazid and rifampicin. Thorax 1995;50:213-214.
Sica DA. Loop diuretic therapy, thiamine balance, and heart failure. Congest Heart Fail 2007;13:244-247.
Altuner D, Cetin N, Suleyman B, Aslan Z, Hacimuftuoglu A, Gulaboglu M, Isaoglu N, I Demiryilmaz I, Suleyman H. Effect of thiamine pyrophosphate on ischemia-reperfusion induced oxidative damage in rat kidney. Indian J Pharmacol 2013;45:339-343.
Acun Delen L, Korkmaz Dişli Z, Taş HG, Kuyrukluyildiz U, Yazici GN, Süleyman B, Kuzucu M, Gürsu C, Suleyman H. The effects of thiamine pyrophosphate on propofol-induced oxidative liver injury and effect on dysfunction. Gen Physiol Biophys 2022;41:63-70.
Turan MI, Cayir A, Cetin N, Suleyman H, Siltelioglu Turan I, Tan H. An investigation of the effect of thiamine pyrophosphate on cisplatin-induced oxidative stress and DNA damage in rat brain tissue compared with thiamine: thiamine and thiamine pyrophosphate effects on cisplatin neuro-toxicity. Hum Exp Toxicol 2014;33:14-21.
Yanakiev S. Effects of cinnamon (Cinnamomum spp.) in dentistry: A review. Molecules 2020;25:4184.
Gruenwald J, Freder J, Armbruester N. Cinnamon and health. Crit Rev Food Sci Nutr 2010;50:822-834.
Dorri M, Hashemitabar S, Hosseinzadeh H. Cinnamon (Cinnamomum zeylanicum) as an antidote or a protective agent against natural or chemical toxicities: a review. Drug Chem Toxicol 2018;41:338-351.
Ho SC, Chang KS, Chang PW. Inhibition of neuroinflammation by cinnamon and its main components. Food Chem 2013;138:2275-2282.
Góth L. A simple method for determination of serum catalase activity and revision of reference range. Clin Chim Acta 1991;196(2-3):143-151.
Tostmann A, Boeree MJ, Aarnoutse RE, de Lange WC, van der Ven AJ, Dekhuijzen R. Antituberculosis drug-induced hepato-toxicity: concise up-todate review. J Gastroenterol Hepatol 2008;23(2):192-202.
Enriquez-Cortina C, Almonte-Becerril M, Clavijo-Cornejo D, Palestino-Domínguez M, Bello-Monroy O, Nuño N, López A, Bucio L, Souza V, Hernández-Pando R, Muñoz L, Gutiérrez-Ruiz MC, Gómez- Quiroz LE. Hepatocyte growth factor protects against isoniazid/rifampicin-induced oxidative liver damage. Toxicol Sci 2013;135:26-36.
Aynaoglu Yildiz G, Yapca OE, Dinc K, Gursul C, Gundogdu B, Aktas M, Suleyman Z, Bulut S, Suleyman H. Stress-associated ovarian damage, infertility, and delay in achieving pregnancy and treatment options. Invest Clin 2023;64:513-523. doi. org/10.54817/IC.v64n4a08
Zhuang X, Li L, Liu T, Zhang R, Yang P, Wang X, Dai L. Mechanisms of isoniazid and rifampicin-induced liver injury and the effects of natural medicinal ingredients: A review. Front Pharmacol 2022;13:1037814.
Pelapelapon AA, Rohmawaty E, Herman H. Evaluation of the hepatoprotective effect of Plantago major extract in a rifampicin-isoniazid induced hepatitis rat model. Trends in Sciences 2023;20:6331- 6331.
Sarandol E, Tas S, Serdar Z, Dirican M. Effects of thiamine treatment on oxidative stress in experimental diabetes. Bratislavske Lekarske Listy 2020;121:235-241.
Bedir Z, Erdem KTO, Can A, Çiçek B, Gülaboğlu M, Süleyman Z, Gürsul C, Mokhtare B, Özçiçek F, Süleyman H. Effect of thiamine pyrophosphate upon possible metamizole-induced liver injury in rats. Int J Pharmacol 2023;19:139-146.
Moselhy SS, Ali HK. Hepatoprotective effect of cinnamon extracts against carbon tetrachloride induced oxidative stress and liver injury in rats. Biol Res 2009;42:93-98.
Naji KM, Al-Khatib BY, Al-Haj NS, D’souza MR. Hepatoprotective activity of melittin on isoniazid-and rifampicin-induced liver injuries in male albino rats. BMC Pharmacol Toxicol 2021;22:1-11.
Zhang G, Zhu J, Zhou Y, Wei Y, Xi L, Qin H, Rao Z, Han M, Ma Y, Wu X. Hesperidin alleviates oxidative stress and upregulates the multidrug resistance protein 2 in isoniazid and rifampicin‐induced liver injury in rats. J Biochem Mol Toxicol 2016;30:342-349.
Sanjay S, Girish C, Toi PC, Bobby Z. Gallic acid attenuates isoniazid and rifampicin-induced liver injury by improving hepatic redox homeostasis through influence on Nrf2 and NF-κB signalling cascades in Wistar Rats. J Pharm Pharmacol 2021;73:473- 486.
El-Kholy M, Faried A, Ghada M. Role of cinnamon extract in the protection against amoxicillin/clavulanate-induced liver damage in rats. IOSR-JPBS. 2019;14:14- 21.
Kaya A, Ceylan AF, Kavutcu M, Santa-maria A, Šoltésová Prnová M, Stefek M, Karasu Ç. A dual-acting aldose reductase inhibitor impedes oxidative and carbonyl stress in tissues of fructose-and strep tozotocin-induced rats: comparison with antioxidant stobadine. Drug ChemToxicol 2023;5:1-11.
He X, Song Y, Wang L, Xu J. Protective effect of pyrrolidine dithiocarbamate on isoniazid/rifampicin‑induced liver injury in rats. Mol Med Rep 2020;21:463-469.
Yang J, Li G, Bao X, Suo Y, Xu H, Deng Y, Feng T, Deng G. Hepatoprotective effects of phloridzin against isoniazid-rifampicin induced liver injury by regulating CYP450 and Nrf2/HO-1 pathway in mice. Chem Pharm Bull 2022;70:805-811.
Wang N, Jiang D, Zhou C, Han X. Alpha-solanine inhibits endothelial inflammation via nuclear factor kappa B signaling pathway. Adv Clin Exp Med. 2023;32:909- 920.
Ozer M, Ince S, Gundogdu B, Aktas M, Uzel K, Gursul C, Suleyman H, Suleyman Z. Effect of thiamine pyrophosphate on cyclophosphamide-induced oxidative ovarian damage and reproductive dysfunction in female rats. Adv Clin Exp Med 2022;31:129-137.
Li B, Li J, Hu S. Cinnamon could improve hepatic steatosis caused by a high‐fat diet via enhancing hepatic beta‐oxidation and inhibiting hepatic lipogenesis, oxidative damage, and inflammation in male rats. J Food Biochem 2022;46:e14077.
Zhai H, Yang B, Fu Y, Zhang D, Li Y, Huang J. Effects of somatostatin in combination with early hemoperfusion on inflammatory, hemorheological and oxidative parameters during the treatment of acute pancreatitis. Invest Clín. 2023;64:41-52.
Wang Y, Che M, Xin J, Zheng Z, Li J, Zhang S. The role of IL -1β and TNF-α in intervertebral disc degeneration. Biomed Pharmacother 2020;131:110660.
Patel S, Chaturvedi A, Dubey N, Shrivastava A, Ganeshpurkar A. Ascorbic acid ameliorates isoniazid-rifampicin-induced hepatocellular damage in rats. iLIVER. 2022;1:72-77.
Ucak T, Karakurt Y, Tasli G, Cimen FK, Icel E, Kurt N, Ahiskali I, Süleyman H. The effects of thiamine pyrophosphate on ethanol induced optic nerve damage. BMC Pharmacol Toxicol 2019;20:40.
Kanuri G, Weber S, Volynets V, Spruss A, Bischoff SC, Bergheim I. Cinnamon extract protects against acute alcohol-induced liver steatosis in mice. J Nutr 2009;139:482-487.
Hussain S, Ashafaq M, Alshahrani S, Siddiqui R, Ahmed RA, Khuwaja G, Islam F. Cinnamon oil against acetaminophen-induced acute liver toxicity by attenuating inflammation, oxidative stress and apoptosis. Toxicol Rep 2020;7:1296-1304.
Yilmaz I, Demiryilmaz I, Turan M, Cetin N, Gul M, Süleyman H. The effects of thiamine and thiamine pyrophosphate on alcohol-induced hepatic damage biomarkers in rats. Eur Rev Med Pharmacol Sci 2015;19:664-670.
Uysal HB, Dağlı B, Yılmaz M, Kahyaoğlu F, Gökçimen A, Ömürlü İK, Demirci B. Biochemical and histological effects of thiamine pyrophosphate against acetaminophen‐induced hepatotoxicity. Basic Clin Pharmacol Toxicol 2016;118:70-76.
Eidi A, Mortazavi P, Bazargan M, Zaringhalam J. Hepatoprotective activity of cinnamon ethanolic extract against CCI4- induced liver injury in rats. Excli Journal. 2012;11:495.
Suárez I, Fünger SM, Kröger S, Rademacher J, Fätkenheuer G, Rybniker J. The diagnosis and treatment of tuberculosis. Dtsch Arztebl Int 2019;116:729-735.
Forget EJ, Menzies D. Adverse reactions to first-line antituberculosis drugs. Expert Opin Drug Saf 2006;5:231-249.
Yew WW, Chang KC, Chan DP. Oxidative stress and first-line antituberculosis drug-induced hepatotoxicity. Antimicrob Agents Chemother 2018;62:e02637-17
Song L, Zhang ZR, Zhang JL, Zhu XB, He L, Shi Z, Gao L, Li Y, Hu B, Feng FM. MicroRNA-122 is involved in oxidative stress in isoniazid-induced liver injury in mice. Genet Mol Res 2015;14:13258-13265.
Ahadpour M, Eskandari MR, Mashayekhi V, Haj Mohammad Ebrahim Tehrani K, Jafarian I, Naserzadeh P, Hosseini MJ. Mitochondrial oxidative stress and dysfunction induced by isoniazid: study on isolated rat liver and brain mitochondria. Drug Chem Toxicol 2016;39:224-232.
Shuhendler AJ, Pu K, Cui L, Uetrecht JP, Rao J. Real-time imaging of oxidative and nitrosative stress in the liver of live animals for drug-toxicity testing. Nat Biotechnol 2014;32:373-380.
Askgaard DS, Wilcke T, Døssing M. He patotoxicity caused by the combined action of isoniazid and rifampicin. Thorax 1995;50:213-214.
Sica DA. Loop diuretic therapy, thiamine balance, and heart failure. Congest Heart Fail 2007;13:244-247.
Altuner D, Cetin N, Suleyman B, Aslan Z, Hacimuftuoglu A, Gulaboglu M, Isaoglu N, I Demiryilmaz I, Suleyman H. Effect of thiamine pyrophosphate on ischemia-reperfusion induced oxidative damage in rat kidney. Indian J Pharmacol 2013;45:339-343.
Acun Delen L, Korkmaz Dişli Z, Taş HG, Kuyrukluyildiz U, Yazici GN, Süleyman B, Kuzucu M, Gürsu C, Suleyman H. The effects of thiamine pyrophosphate on propofol-induced oxidative liver injury and effect on dysfunction. Gen Physiol Biophys 2022;41:63-70.
Turan MI, Cayir A, Cetin N, Suleyman H, Siltelioglu Turan I, Tan H. An investigation of the effect of thiamine pyrophosphate on cisplatin-induced oxidative stress and DNA damage in rat brain tissue compared with thiamine: thiamine and thiamine pyrophosphate effects on cisplatin neuro-toxicity. Hum Exp Toxicol 2014;33:14-21.
Yanakiev S. Effects of cinnamon (Cinnamomum spp.) in dentistry: A review. Molecules 2020;25:4184.
Gruenwald J, Freder J, Armbruester N. Cinnamon and health. Crit Rev Food Sci Nutr 2010;50:822-834.
Dorri M, Hashemitabar S, Hosseinzadeh H. Cinnamon (Cinnamomum zeylanicum) as an antidote or a protective agent against natural or chemical toxicities: a review. Drug Chem Toxicol 2018;41:338-351.
Ho SC, Chang KS, Chang PW. Inhibition of neuroinflammation by cinnamon and its main components. Food Chem 2013;138:2275-2282.
Góth L. A simple method for determination of serum catalase activity and revision of reference range. Clin Chim Acta 1991;196(2-3):143-151.
Tostmann A, Boeree MJ, Aarnoutse RE, de Lange WC, van der Ven AJ, Dekhuijzen R. Antituberculosis drug-induced hepato-toxicity: concise up-todate review. J Gastroenterol Hepatol 2008;23(2):192-202.
Enriquez-Cortina C, Almonte-Becerril M, Clavijo-Cornejo D, Palestino-Domínguez M, Bello-Monroy O, Nuño N, López A, Bucio L, Souza V, Hernández-Pando R, Muñoz L, Gutiérrez-Ruiz MC, Gómez- Quiroz LE. Hepatocyte growth factor protects against isoniazid/rifampicin-induced oxidative liver damage. Toxicol Sci 2013;135:26-36.
Aynaoglu Yildiz G, Yapca OE, Dinc K, Gursul C, Gundogdu B, Aktas M, Suleyman Z, Bulut S, Suleyman H. Stress-associated ovarian damage, infertility, and delay in achieving pregnancy and treatment options. Invest Clin 2023;64:513-523. doi. org/10.54817/IC.v64n4a08
Zhuang X, Li L, Liu T, Zhang R, Yang P, Wang X, Dai L. Mechanisms of isoniazid and rifampicin-induced liver injury and the effects of natural medicinal ingredients: A review. Front Pharmacol 2022;13:1037814.
Pelapelapon AA, Rohmawaty E, Herman H. Evaluation of the hepatoprotective effect of Plantago major extract in a rifampicin-isoniazid induced hepatitis rat model. Trends in Sciences 2023;20:6331- 6331.
Sarandol E, Tas S, Serdar Z, Dirican M. Effects of thiamine treatment on oxidative stress in experimental diabetes. Bratislavske Lekarske Listy 2020;121:235-241.
Bedir Z, Erdem KTO, Can A, Çiçek B, Gülaboğlu M, Süleyman Z, Gürsul C, Mokhtare B, Özçiçek F, Süleyman H. Effect of thiamine pyrophosphate upon possible metamizole-induced liver injury in rats. Int J Pharmacol 2023;19:139-146.
Moselhy SS, Ali HK. Hepatoprotective effect of cinnamon extracts against carbon tetrachloride induced oxidative stress and liver injury in rats. Biol Res 2009;42:93-98.
Naji KM, Al-Khatib BY, Al-Haj NS, D’souza MR. Hepatoprotective activity of melittin on isoniazid-and rifampicin-induced liver injuries in male albino rats. BMC Pharmacol Toxicol 2021;22:1-11.
Zhang G, Zhu J, Zhou Y, Wei Y, Xi L, Qin H, Rao Z, Han M, Ma Y, Wu X. Hesperidin alleviates oxidative stress and upregulates the multidrug resistance protein 2 in isoniazid and rifampicin‐induced liver injury in rats. J Biochem Mol Toxicol 2016;30:342-349.
Sanjay S, Girish C, Toi PC, Bobby Z. Gallic acid attenuates isoniazid and rifampicin-induced liver injury by improving hepatic redox homeostasis through influence on Nrf2 and NF-κB signalling cascades in Wistar Rats. J Pharm Pharmacol 2021;73:473- 486.
El-Kholy M, Faried A, Ghada M. Role of cinnamon extract in the protection against amoxicillin/clavulanate-induced liver damage in rats. IOSR-JPBS. 2019;14:14- 21.
Kaya A, Ceylan AF, Kavutcu M, Santa-maria A, Šoltésová Prnová M, Stefek M, Karasu Ç. A dual-acting aldose reductase inhibitor impedes oxidative and carbonyl stress in tissues of fructose-and strep tozotocin-induced rats: comparison with antioxidant stobadine. Drug ChemToxicol 2023;5:1-11.
He X, Song Y, Wang L, Xu J. Protective effect of pyrrolidine dithiocarbamate on isoniazid/rifampicin‑induced liver injury in rats. Mol Med Rep 2020;21:463-469.
Yang J, Li G, Bao X, Suo Y, Xu H, Deng Y, Feng T, Deng G. Hepatoprotective effects of phloridzin against isoniazid-rifampicin induced liver injury by regulating CYP450 and Nrf2/HO-1 pathway in mice. Chem Pharm Bull 2022;70:805-811.
Wang N, Jiang D, Zhou C, Han X. Alpha-solanine inhibits endothelial inflammation via nuclear factor kappa B signaling pathway. Adv Clin Exp Med. 2023;32:909- 920.
Ozer M, Ince S, Gundogdu B, Aktas M, Uzel K, Gursul C, Suleyman H, Suleyman Z. Effect of thiamine pyrophosphate on cyclophosphamide-induced oxidative ovarian damage and reproductive dysfunction in female rats. Adv Clin Exp Med 2022;31:129-137.
Li B, Li J, Hu S. Cinnamon could improve hepatic steatosis caused by a high‐fat diet via enhancing hepatic beta‐oxidation and inhibiting hepatic lipogenesis, oxidative damage, and inflammation in male rats. J Food Biochem 2022;46:e14077.
Zhai H, Yang B, Fu Y, Zhang D, Li Y, Huang J. Effects of somatostatin in combination with early hemoperfusion on inflammatory, hemorheological and oxidative parameters during the treatment of acute pancreatitis. Invest Clín. 2023;64:41-52.
Wang Y, Che M, Xin J, Zheng Z, Li J, Zhang S. The role of IL -1β and TNF-α in intervertebral disc degeneration. Biomed Pharmacother 2020;131:110660.
Patel S, Chaturvedi A, Dubey N, Shrivastava A, Ganeshpurkar A. Ascorbic acid ameliorates isoniazid-rifampicin-induced hepatocellular damage in rats. iLIVER. 2022;1:72-77.
Ucak T, Karakurt Y, Tasli G, Cimen FK, Icel E, Kurt N, Ahiskali I, Süleyman H. The effects of thiamine pyrophosphate on ethanol induced optic nerve damage. BMC Pharmacol Toxicol 2019;20:40.
Kanuri G, Weber S, Volynets V, Spruss A, Bischoff SC, Bergheim I. Cinnamon extract protects against acute alcohol-induced liver steatosis in mice. J Nutr 2009;139:482-487.
Hussain S, Ashafaq M, Alshahrani S, Siddiqui R, Ahmed RA, Khuwaja G, Islam F. Cinnamon oil against acetaminophen-induced acute liver toxicity by attenuating inflammation, oxidative stress and apoptosis. Toxicol Rep 2020;7:1296-1304.
Yilmaz I, Demiryilmaz I, Turan M, Cetin N, Gul M, Süleyman H. The effects of thiamine and thiamine pyrophosphate on alcohol-induced hepatic damage biomarkers in rats. Eur Rev Med Pharmacol Sci 2015;19:664-670.
Uysal HB, Dağlı B, Yılmaz M, Kahyaoğlu F, Gökçimen A, Ömürlü İK, Demirci B. Biochemical and histological effects of thiamine pyrophosphate against acetaminophen‐induced hepatotoxicity. Basic Clin Pharmacol Toxicol 2016;118:70-76.
Eidi A, Mortazavi P, Bazargan M, Zaringhalam J. Hepatoprotective activity of cinnamon ethanolic extract against CCI4- induced liver injury in rats. Excli Journal. 2012;11:495.
Publicado
2024-08-20
Cómo citar
Yeter, B., Mammadov, R., Koc, Z., Bulut, S., Tastan, T. B., Gulaboglu, M., & Suleyman, H. (2024). Protective effects of thiamine pyrophosphate and cinnamon against oxidative liver damage induced by an isoniazid and rifampicin combination in rats.: Efectos protectores del pirofosfato de tiamina y la canela contra el daño hepático oxidativo inducido por la combinación de isoniazida y rifampicina en ratas. Investigación Clínica, 65(3), 321-334. https://doi.org/10.54817/IC.v65n3a05
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