Intestino permeable. Importancia para la salud y bienestar
Leaky gut. Importance for health and well-being
Keywords:
dysbiosis, gut barrier, probiotic
Abstract
The gut microbiota maintains the integrity of this intestinal barrier. Intestinal dysbiosis is manifested by the presence of pro-inflammatory bacterial strains, such as the Bacteroides species. There are 3 ways to modulate the composition of the intestinal microbiota: supplementation with probiotics, intervention with specific microbial species using medications, and fecal transplantation with healthy intestinal microbiome. The development of new therapeutic tools that modify the composition of the intestinal microbiota will make it possible in the future to control a large group of diseases.
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References
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Delaune V, Orci LA, Lacotte S, Peloso A, Schrenzel J, Lazarevic V, et al. Fecal microbiota transplantation: a promising strategy in preventing the progression of non-alcoholic steatohepatitis and improving the anti-cancer immune response. Expert Opin Biol Ther. (2018) 18:1061–71.
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Chang CJ, Lin CS, Lu CC, Martel J, Ko YF, Ojcius DM, et al. Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota. Nat Commun. (2015) 6:7489.
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Mu Q, Kirby J, Reilly CM, Luo XM. Leaky gut as a danger signal for autoimmune diseases. Front Immunol. 2017;8:598.
Belizario JE, Faintuch J, Garay-Malpartida M. Gut microbiome dysbiosis and immunometabolism: new frontiers for treatment of metabolic diseases. MediatInflamm 2018:2037838.
Yang G, Wei J, Liu P, Zhang Q, Tian Y, Hou G, et al. Role of the gut microbiota in type 2 diabetes and related diseases. Metabolism. (2021) 117:154712: 154712.
Takiishi T, Fenero CIM, Camara NOS. Intestinal barrier and gut microbiota: shaping our immune responses throughout life. Tissue Barriers. (2017) 5:e1373208.
Pasini E, Corsetti G, Assanelli D, Testa C, Romano C, Dioguardi FS, et al. Effects of chronic exercise on gut microbiota and intestinal barrier in human with type 2 diabetes. Minerva Med. (2019) 110:3–11.
Sharma S, Tripathi P. Gut microbiome and type 2 diabetes: where we are and where to go? J Nutr Biochem. (2019) 63:101–8.
Salazar J, Angarita L, Morillo V, Navarro C, Martinez MS, Chacin M, et al. Microbiota and diabetes mellitus: role of lipid mediators. Nutrients. (2020) 12:3039.
Han Y, Wu L, Ling Q, Wu P, Zhang C, Jia L, et al. Intestinal dysbiosis correlates with sirolimus-induced metabolic disorders in mice. Transplantation. (2021) 105:1017–29.
Zhou J, Li M, Chen Q, Li X, Chen L, Dong Z, et al. Programmable probiotics modulate inflammation and gut microbiota for inflammatory bowel disease treatment after effective oral delivery. Nat Commun. (2022) 13:3432: 3432.
Zhou D, Pan Q, Shen F, Cao HX, Ding WJ, Chen YW, et al. Total fecal microbiota transplantation alleviates high-fat diet-induced steatohepatitis in mice via beneficial regulation of gut microbiota. Sci Rep. (2017) 7:1529: 1529.
Delaune V, Orci LA, Lacotte S, Peloso A, Schrenzel J, Lazarevic V, et al. Fecal microbiota transplantation: a promising strategy in preventing the progression of non-alcoholic steatohepatitis and improving the anti-cancer immune response. Expert Opin Biol Ther. (2018) 18:1061–71.
Li Y, Liu T, Yan C, Xie R, Guo Z, Wang S, et al. Diammonium glycyrrhizinate protects against nonalcoholic fatty liver disease in mice through modulation of gut microbiota and restoration of intestinal barrier. Mol Pharm. (2018) 15:3860–70.
Xu W, Lin L, Liu A, Zhang T, Zhang S, Li Y, et al. L-Theanine affects intestinal mucosal immunity by regulating short-chain fatty acid metabolism under dietary fiber feeding. Food Funct. (2020 Sep 23)11:8369–79.
Chang CJ, Lin CS, Lu CC, Martel J, Ko YF, Ojcius DM, et al. Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota. Nat Commun. (2015) 6:7489.
Xie WR, Yang XY, Deng ZH, Zheng YM, Zhang R, Wu LH, et al. Effects of washed microbiota transplantation on serum uric acid levels, symptoms, and intestinal barrier function in patients with acute and recurrent gout: a pilot study. Dig Dis. (2022) 40:684–90.
Weston KS, Wisloff U, Coombes JS. High-intensity interval training in patients with lifestyle-induced cardiometabolic disease: a systematic review and meta-analysis. Br J Sports Med. (2014) 48:1227– 34.
Guzman A, Navarro E, Obando L, Pacheco J, Quiros K, Vasquez L, et al. Effectiveness of interventions for the reversal of a metabolic syndrome diagnosis: an update of a meta-analysis of mixed treatment comparison studies. Biomedica. (2019) 39:647–62.
Published
2024-05-23
How to Cite
Lizarzábal García, M. (2024). Intestino permeable. Importancia para la salud y bienestar: Leaky gut. Importance for health and well-being. Revista Profesional HígadoSano, (27), 11-15. https://doi.org/10.5281/zenodo.11265113
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