Mechanisms of Resistance to Glycopeptides in Staphylococcus aureus

  • Maribel Castellano González Chair of General Bacteriology. School of Bioanalysis. University of Zulia.
  • Armindo Perozo Mena Chair of Professional Practice of Bacteriology. School of Bioanalysis. University of Zulia. Venezuela. Bacteriological Reference Center - Autonomous Service University Hospital of Maracaibo. Venezuela.
Keywords: Staphylococcus aureus, glycopeptides, vancomycin, teicoplanin, resistance mechanisms

Abstract

Glycopeptides (vancomycin and teicoplanin) are an alternative therapeutic in the treatment of severe infections by methicillin-resistant S. aureus strains. However, two resistance mechanisms of S. aureus have already been described: low-level resistance, characterized by an abnormal thickening of the cellular wall, present in the VISA strains, and high-level resistance, mediated by the vanA operon, which causes the replacement of D-ala - D-ala terminal residues by D-ala-D-lac, decreasing its affinity for the antibiotic. This review summarizes the history of the emergence of glycopeptide resistance in S. aureus and considers the mechanisms that determine the resistance in these organisms as a background for understanding the need and potential roles of new agents of this kind.

Published
2010-08-07
How to Cite
1.
Castellano González M, Perozo Mena A. Mechanisms of Resistance to Glycopeptides in Staphylococcus aureus. Kasmera [Internet]. 2010Aug.7 [cited 2024Oct.20];38(1):36-4. Available from: https://produccioncientificaluz.org./index.php/kasmera/article/view/4854
Issue
Vol. 38 No. 1 (2010)
Section
Narrative Review

Copyright (c) 2010 Maribel Castellano González, Armindo Perozo Mena

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Kasmera journal is registered under a Creative Commons an Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0), available at: https://creativecommons.org/licenses/by-nc-sa/4.0/deed.en; which guarantees the freedom to share-copy and redistribute the material in any medium or format and adapt-remix, transform and build from the material, provided that the name of the authors, the Department of Infectious and Tropical Diseases, Zulia´s University and Kasmera Journal, you must also provide a link to the original document and indicate if changes have been made.

The Department of Infectious and Tropical Diseases, University of Zulia and Kasmera Journal do not retain the rights to published manuscript and the contents are the sole responsibility of the authors, who retain their moral, intellectual, privacy and publicity rights. The guarantee on the intervention of the manuscript (revision, correction of style, translation, layout) and its subsequent dissemination is granted through a license of use and not through a transfer of rights, which represents the Kasmera Journal and Department Infectious Diseases, University of Zulia are exempt from any liability that may arise from ethical misconduct by the authors.

Kasmera is considered a green SHERPA/RoMEO journal, that is, it allows self-archiving of both the pre-print (draft of a manuscript) and the post-print (the corrected and peer-reviewed version) and even the final version (layout as it will be published in the journal) both in personal repositories and in institutional and databases.