Synthesis, characterization and antimicrobial activity of a 7-chloro-4- aminoquinolinesemicarbazone derivative
Síntesis, caracterización y actividad antimicrobiana de un derivado 7-cloro-4-aminoquinolinsemicarbazona
Keywords:
semicarbazone, 7-chloro-4-aminoquinoline, antimicrobial activity, molecular hybridization
Abstract
This study describes the synthesis, characterization and antimicrobial activity evaluation of 2-(1-{3-[(7-chloroquinolin-4-yl)amino]phenyl}ethylidene)hydrazinecarboxamide (5), which was designed and synthesized applying a molecular hybridization strategy, considering two pharmacophoric portions: 7-chloro-4-aminoquinoline and semicarbazone; both fractions have been related to antimicrobial activity exhibited by a series of derivatives synthesized. Compound 5 was characterized using 1H NMR, 13C NMR and Electrospray Ionization Mass Spectrometry (ESI-MS) studies. Biological evaluation showed that compound 5 exhibited antimicrobial activity against bacteria Gram (-) Pseudomona aeruginosa, comparable with the activities corresponding to Amikacin, Ampicillin/Sulbactam and Ofloxacin.
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References
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Published
2018-12-20
How to Cite
Parra, Y. de J., Ferrer, R. E., & Charris, J. (2018). Synthesis, characterization and antimicrobial activity of a 7-chloro-4- aminoquinolinesemicarbazone derivative: Síntesis, caracterización y actividad antimicrobiana de un derivado 7-cloro-4-aminoquinolinsemicarbazona . Ciencia, 26(3-4), 89-94. https://doi.org/10.5281/zenodo.5590947
Section
Química/Chemistry
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