El efecto de la intoxicación aguda por Monóxido de Carbono en la necrosis cardíaca en ratas: en relación con los niveles de Adiponectina

• Gul Sahika Gökdemir Mardin Artuklu University, Faculty of Medicine, Department of Physiology. Mardin, Türkiye https://orcid.org/0000-0002-8691-1504
• Sümeyye Çakmak University of Health Science, Haseki Education and Research Hospital, Emergency Department. Istanbul, Türkiye https://orcid.org/0000-0001-9573-8611
• Berjan Demirtas Istanbul University–Cerrahpaşa, Vocational School Veterinary Medicine, Plant and Animal Production, Equine and Training Program. Istanbul, Türkiye https://orcid.org/0000-0002-0371-6376
• Mehmet Tahir Gökdemir Mardin Artuklu University, Faculty of Medicine, Emergency Department. Mardin, Türkiye https://orcid.org/0000-0002-5546-9653
• Ozgur Sogut University of Health Science, Haseki Education and Research Hospital, Emergency Department. Istanbul, Türkiye https://orcid.org/0000-0003-3365-3713
• Revşa Evin Canpolat–Erkan Dicle University, Faculty of Medicine, Department of Medical Biochemistry. Diyarbakır, Türkiye https://orcid.org/0000-0003-2906-8589
• Fırat Aşır Dicle University, Faculty of Medicine, Department of Histology. Diyarbakır, Türkiye https://orcid.org/0000-0002-6384-9146
• Beran Yokus Dicle University, Faculty of Medicine, Department of Medical Biochemistry. Diyarbakır, Türkiye https://orcid.org/0000-0003-4585-3712

DOI: https://doi.org/10.52973/rcfcv-e35532

Palabras clave: Adiponectina, ntoxicación por monóxido de carbono, corazón, terapia de oxígeno, rata

Resumen

Con el objetivo de investigar los efectos de la intoxicación aguda por monóxido de carbono (CO) y la terapia de oxígeno subsiguiente en la necrosis cardíaca en ratas, con un enfoque específico en los niveles de adiponectina, veintiuna ratas albinas Wistar machos fueron divididas en tres grupos (Control, CO, CO+O₂). El grupo de control fue colocado en un recipiente y expuesto al aire ambiente durante 30 min. Se indujo intoxicación aguda por CO en el grupo CO y el grupo CO+O₂ al exponer a los ratas a gas CO durante 30 min. Después de la exposición al CO, el grupo CO+O₂ recibió terapia de oxígeno durante 30 min, mientras que el grupo CO no recibió ninguna intervención adicional. La eutanasia de los animales se realizó mediante punción cardíaca bajo anestesia, siguiendo los procedimientos éticos aprobados. Se midieron los niveles de carboxihemoglobina (COHb), creatina quinasa (CK), banda de creatina quinasa miocárdica (CK–MB), proteína C–reactiva (CRP) y lactato deshidrogenasa (LDH), así como los niveles de adiponectina cardíaca y sérica. La intoxicación por CO causó necrosis en el tejido cardíaco; sin embargo, la terapia de oxígeno alivió el efecto negativo del CO en la lesión cardíaca. Los niveles de COHb y LDH en el grupo de CO aumentaron, mientras que tanto los niveles de adiponectina cardíaca como sérica disminuyeron (todos, P<0.05). No se observaron cambios en los niveles de CK, CK–MB y CRP entre los grupos (todos, P>0,05). La terapia de oxígeno disminuyó los niveles de COHb, pero aumentó tanto los niveles de adiponectina cardíaca como sérica (todos, P<0.05). La adiponectina y LDH pueden servir como biomarcadores potenciales para el diagnóstico temprano de la necrosis cardíaca causada por la intoxicación aguda por CO. La valoración o cuantificación de adiponectina también puede ser útil para el pronóstico temprano de la necrosis cardíaca después de la terapia de oxígeno.

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